一氧化二氮和河豚毒素对网状脊髓抑制通路的阻断作用。
Blockade of the reticulospinal inhibitory pathway by nitrous oxide and tetrodotoxin.
作者信息
Frank G B, Ota M
出版信息
Br J Pharmacol. 1972 Sep;46(1):23-31. doi: 10.1111/j.1476-5381.1972.tb06845.x.
Abstract
- The effects of nitrous oxide and tetrodotoxin were investigated on the reticulospinal inhibitory pathway in the acutely decerebrated cat.2. Both agents abolished the reticular inhibition of the segmental reflex potentials before they blocked either the segmental reflex potentials or the reticular facilitation of the reflex potentials.3. These results confirmed the hypothesis that preferential block of the reticulospinal inhibitory pathway might be an important neural mechanism of the excitement stage of anaesthesia.
摘要
研究了一氧化二氮和河豚毒素对急性去大脑猫网状脊髓抑制通路的影响。
在阻断节段性反射电位或网状结构对反射电位的易化作用之前，这两种药物均消除了节段性反射电位的网状抑制。
这些结果证实了以下假说，即网状脊髓抑制通路的优先阻断可能是麻醉兴奋期的重要神经机制。
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2
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Am J Physiol. 1960 May;198:934-8. doi: 10.1152/ajplegacy.1960.198.5.934.
3
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J Neurophysiol. 1964 May;27:408-28. doi: 10.1152/jn.1964.27.3.408.
4
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J Gen Physiol. 1964 May;47(5):965-74. doi: 10.1085/jgp.47.5.965.
5
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Br J Pharmacol Chemother. 1963 Aug;21(1):1-9. doi: 10.1111/j.1476-5381.1963.tb01497.x.
6
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7
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