静脉注射磷酸丙吡胺对复发性阵发性心动过速的影响。
The effect of intravenous disopyramide phosphate on recurrent paroxysmal tachycardias.
作者信息
Camm J, Ward D, Spurrell R A
出版信息
Br J Clin Pharmacol. 1979 Nov;8(5):441-9. doi: 10.1111/j.1365-2125.1979.tb01023.x.
1 Reccurent paroxysmal atrial, atrioventricular and ventricular tachycardias in 50 patients without acute coronary insufficiency, heart failure or metabolic abnormlity were treated with disopyramide phosphate in a dose of 2 mg/kg body weight infused over 5 min. 2 Conversion to sinus rhythm within 10 min of the completed infusion occurred in 10 of 14 (71%) patients with paroxysmal 'lone' atrial fibrillation, 3 of 7 (43%) patients with paroxysmal atrial flutter, 6 of 9 (67%) patients with paroxysmal atrial tachycardia, 5 of 9 (56%) patients with paroxysmal atrioventricular tachycardia associated with the Wolff-Parkinson-White syndrome and 8 of 11 (73%) patients with paroxysmal ventricular tachycardia. 3 Side effects: significant systemic hypotension in 3, high grade AV block in 1, an increased ventricular response producing symptoms in 4, post conversion asystole in 1 land sinus bradycardia in 2. 4 The anti-arrhythmic effect and arrhythmogenic side effects may be related to both the direct membrane stabilizing effect and the anticholinergic effect of disopyramide.
对50例无急性冠状动脉供血不足、心力衰竭或代谢异常的复发性阵发性房性、房室交界性和室性心动过速患者，给予磷酸丙吡胺，剂量为2mg/kg体重，于5分钟内静脉输注。
在输注结束后10分钟内，14例阵发性“孤立性”心房颤动患者中有10例（71%）、7例阵发性心房扑动患者中有3例（43%）、9例阵发性房性心动过速患者中有6例（67%）、9例与预激综合征相关的阵发性房室交界性心动过速患者中有5例（56%）以及11例阵发性室性心动过速患者中有8例（73%）转为窦性心律。
副作用：3例出现明显的全身性低血压，1例出现高度房室传导阻滞，4例心室反应增强并产生症状，1例转复后出现心搏停止，2例出现窦性心动过缓。
抗心律失常作用和致心律失常副作用可能与丙吡胺的直接膜稳定作用和抗胆碱能作用均有关。
Zotero 插件