广岛血红蛋白中的配体动力学。
Ligand kinetics in hemoglobin Hiroshima.
作者信息
Nagel R L, Gibson Q H, Hamilton H B
出版信息
J Clin Invest. 1971 Aug;50(8):1772-5. doi: 10.1172/JCI106666.
Abstract
Hemoglobin Hiroshima is an electrophoretically fast-moving variant with a fourfold increase in oxygen affinity and a decreased Bohr effect. Based on a decreased rate of dissociation of O(2) in the presence of dithionite and an increased rate of binding of CO by the deoxy form, we have concluded that the kinetic basis of the high affinity exhibited by Hb Hiroshima is the concurrence of a faster combination rate and a slower dissociation rate for ligands.
摘要
广岛血红蛋白是一种电泳快速移动的变体，其氧亲和力增加四倍，玻尔效应降低。基于在连二亚硫酸盐存在下O₂解离速率降低以及脱氧形式与CO结合速率增加，我们得出结论，广岛血红蛋白所表现出的高亲和力的动力学基础是配体结合速率更快和解离速率更慢的同时出现。
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