Mahaffey K R, Vanderveen J E
Environ Health Perspect. 1979 Apr;29:81-7. doi: 10.1289/ehp.792981.
Nutritional status can substantially modify the toxicity of environmental pollutants. Investigations with experimental animals and epidemiological observations on humans have established the role of nutrition in altering susceptibility to a variety of pollutants including pesticides and heavy metals. The degree of nutritional deficiency that alters susceptibility need not be severe. Frequently only biochemical indications of nutritional deficiency can be associated with changes in the dose-response of an animal or person to a toxic compound.
营养状况可显著改变环境污染物的毒性。对实验动物的研究以及对人类的流行病学观察已证实营养在改变对包括农药和重金属在内的多种污染物的易感性方面所起的作用。改变易感性的营养缺乏程度不一定严重。通常,只有营养缺乏的生化指标才可能与动物或人对有毒化合物的剂量反应变化相关。