Messmer K, Jesch F, Endrich B, Hobbhahn J, Peters W, Schoenberg M
Eur Surg Res. 1979;11(3):161-71. doi: 10.1159/000128063.
Solutions of conventional stoma-free hemoglobin (SFH) and of pyridoxylated stoma-free hemoglobin (SFH-PLP) were compared in a dog model of reanimation from severe arterial blood loss. SFH and SFH-PLP restored central hemodynamics after infusion without yielding significant differences between the experimental groups. To cope with the developing hypovolemia, Ringer's lactate load amounted to about 120 ml/kg, edema formation was not encountered. Skeletal muscle oxygenation was studied by means of a multiwire platin electrode. The infusion of SFH-PLP was associated with a shift to the right of the cumulative PO2-distribution curve, indicating better tissue oxygenation. Oxygen was not unloaded from SFH in plasma unless the oxygen extraction from red cell hemoglobin exceeded 40%. Oxygen unloading was, however, improved when SFH-PLP with low oxygen affinity was used. Thus, SFH-PLP merits further consideration as a short-term oxygen-carrying blood substitute.
在严重动脉失血复苏的犬模型中，对传统无基质血红蛋白（SFH）溶液和吡哆醛化无基质血红蛋白（SFH-PLP）溶液进行了比较。输注后，SFH和SFH-PLP恢复了中心血流动力学，各实验组之间无显著差异。为应对逐渐发展的低血容量，乳酸林格氏液输注量约为120 ml/kg，未出现水肿形成。通过多丝铂电极研究骨骼肌氧合情况。输注SFH-PLP与累积PO2分布曲线右移相关，表明组织氧合更好。除非红细胞血红蛋白的氧摄取超过40%，否则血浆中的SFH不会释放氧气。然而，当使用低氧亲和力的SFH-PLP时，氧释放得到改善。因此，SFH-PLP作为一种短期携氧血液替代品值得进一步考虑。
