Turner G C, Field A M, Lasheen R M, Tood R M, White G B, Porter A A
Arch Dis Child. 1971 Oct;46(249):616-22. doi: 10.1136/adc.46.249.616.
A woman in the antigenaemic phase of acute hepatitis gave birth to a female child after 35 weeks' gestation. No antigen was detected in the child's blood at birth or after 32 days. At 59 days, however, the test for antigen was strongly positive. The child remained well with no jaundice or other clinical evidence of disease, but positive tests for antigen and raised serum alanine transferase levels persisted throughout the first 2 years of life. Evidence from serological tests and electron microscopical appearances suggested that the infant developed some antibody but not sufficient to eliminate the antigen. The significance of these findings is discussed in relation to long-term carriage of serum hepatitis virus by healthy subjects, and the possibility of `vertical transmission' from mother to child.
一名处于急性肝炎抗原血症期的女性在妊娠35周后产下一名女婴。婴儿出生时及出生32天后血液中均未检测到抗原。然而，在59天时，抗原检测呈强阳性。该婴儿一直健康，无黄疸或其他疾病的临床证据，但在生命的头两年中，抗原检测一直呈阳性，血清丙氨酸转氨酶水平持续升高。血清学检测和电子显微镜观察结果表明，婴儿产生了一些抗体，但不足以清除抗原。结合健康受试者长期携带血清肝炎病毒的情况以及母婴“垂直传播”的可能性，对这些发现的意义进行了讨论。
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