人体血浆中十七种氨基酸中铜（II）离子和锌（II）离子的计算分布情况。
The computed distribution of copper(II) and zinc(II) ions among seventeen amino acids present in human blood plasma.
作者信息
Hallman P S, Perrin D D, Watt A E
出版信息
Biochem J. 1971 Feb;121(3):549-55. doi: 10.1042/bj1210549.
Abstract
The equilibrium distribution of copper(II) and zinc(II) ions among a mixture of 17 amino acids has been computed from stability-constant and blood-plasma-composition data. At pH7.4, 98% of the copper(II) in the simulated plasma solution is co-ordinated to histidine and cystine, predominantly as the mixed-ligand complexes Cu.His.Cystine and [Cu.H.His.Cystine]. Approximately half of the zinc(II) is co-ordinated to cysteine and histidine, but appreciable complex-formation occurs with most of the other amino acids. Stability constants are given for copper(II) and zinc(II) amino acid complexes, including some mixed-ligand species, at 37 degrees C and I=0.15m.
摘要
已根据稳定常数和血浆成分数据计算出铜（II）和锌（II）离子在17种氨基酸混合物中的平衡分布。在pH7.4时，模拟血浆溶液中98%的铜（II）与组氨酸和胱氨酸配位，主要形成混合配体络合物Cu.His.Cystine和[Cu.H.His.Cystine]。大约一半的锌（II）与半胱氨酸和组氨酸配位，但与大多数其他氨基酸也会发生明显的络合。给出了37℃和I = 0.15m时铜（II）和锌（II）氨基酸络合物（包括一些混合配体物种）的稳定常数。
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