人体血浆中十七种氨基酸中铜（II）离子和锌（II）离子的计算分布情况。
The computed distribution of copper(II) and zinc(II) ions among seventeen amino acids present in human blood plasma.
作者信息
Hallman P S, Perrin D D, Watt A E
出版信息
Biochem J. 1971 Feb;121(3):549-55. doi: 10.1042/bj1210549.
Abstract
The equilibrium distribution of copper(II) and zinc(II) ions among a mixture of 17 amino acids has been computed from stability-constant and blood-plasma-composition data. At pH7.4, 98% of the copper(II) in the simulated plasma solution is co-ordinated to histidine and cystine, predominantly as the mixed-ligand complexes Cu.His.Cystine and [Cu.H.His.Cystine]. Approximately half of the zinc(II) is co-ordinated to cysteine and histidine, but appreciable complex-formation occurs with most of the other amino acids. Stability constants are given for copper(II) and zinc(II) amino acid complexes, including some mixed-ligand species, at 37 degrees C and I=0.15m.
摘要
已根据稳定常数和血浆成分数据计算出铜（II）和锌（II）离子在17种氨基酸混合物中的平衡分布。在pH7.4时，模拟血浆溶液中98%的铜（II）与组氨酸和胱氨酸配位，主要形成混合配体络合物Cu.His.Cystine和[Cu.H.His.Cystine]。大约一半的锌（II）与半胱氨酸和组氨酸配位，但与大多数其他氨基酸也会发生明显的络合。给出了37℃和I = 0.15m时铜（II）和锌（II）氨基酸络合物（包括一些混合配体物种）的稳定常数。
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本文引用的文献
1
THE CONCENTRATIONS OF CYSTEINE AND CYSTINE IN HUMAN BLOOD PLASMA.
J Clin Invest. 1960 Nov;39(11):1633-8. doi: 10.1172/JCI104186.
2
COPPER METABOLISM IN NORMAL SUBJECTS.
Am J Clin Nutr. 1964 Apr;14:224-32. doi: 10.1093/ajcn/14.4.224.
3
The free amino acids of human blood plasma.
J Biol Chem. 1954 Dec;211(2):915-26.
4
The state of copper in human serum: evidence for an amino acid-bound fraction.
J Clin Invest. 1967 Apr;46(4):646-58. doi: 10.1172/JCI105566.
5
A pH-titration cell for precise measurements.
Chem Ind. 1966 Apr 16;16:661.
6
Multiple equilibria in assemblages of metal ions and complexing species: a model for biological systems.
Nature. 1965 Apr 10;206(980):170-1. doi: 10.1038/206170a0.
7
Structure of Mn2+ and Cu2+ complexes with L-methionine, S-methyl-L-cysteine, L-threonine and L-serine.
Biochim Biophys Acta. 1969 Jul 30;184(2):318-28. doi: 10.1016/0304-4165(69)90034-8.
8
Evidence for albumin--cu(II)--amino acid ternary complex.
Can J Biochem. 1968 Jun;46(6):601-7. doi: 10.1139/o68-092.
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