姐妹中的急性髓细胞白血病及白血病相关抗原
Acute myelocytic leukaemia and leukaemia-associated antigens in sisters.
作者信息
Pendergrass T W, Mann D L, Stoller R G, Halterman R H, Fraumeni J F
出版信息
Lancet. 1975 Sep 6;2(7932):429-31. doi: 10.1016/s0140-6736(75)90844-2.
PMID:51238
Abstract
In a sibship of 5 brothers and 7 sisters, 3 sisters died from acute myelocytic leukaemia while a 4th probably had the same disease. Laboratory studies on the close relatives revealed that a 5th sister had persistently high erythrocyte sedimentation-rates and serum-IgM levels and serological evidence of acute leukaemia-associated antigens. These findings suggest a possible preleukaemic state in this patient.
摘要
在一个有5个兄弟和7个姐妹的家庭中，3个姐妹死于急性髓细胞白血病，而第4个姐妹可能也患有同样的疾病。对其近亲进行的实验室研究显示，第5个姐妹的红细胞沉降率和血清IgM水平持续偏高，并且有急性白血病相关抗原的血清学证据。这些发现表明该患者可能处于白血病前期状态。
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