沙林透过离体人皮肤的研究II：溶剂预处理对渗透性的影响

Sarin transport across excised human skin II: Effect of solvent pretreatment on permeability.

作者信息

Matheson L E, Wurster D E, Ostrenga J A

出版信息

J Pharm Sci. 1979 Nov;68(11):1410-3. doi: 10.1002/jps.2600681119.

Abstract

The effect of pretreating callus membranes with dimethyl sulfoxide, dimethylacetamide, dimethylformamide, formamide, dioxane, or methyl orthoformate on sarin permeability was studied at three temperatures to determine the activation energy for transport. In addition, the effect of membrane pretreatment on permeability through callus membranes from either a sarin-carboxypolymethylene gel or a sarin-polymethyl methacrylate gel was studied.

摘要

研究了在三种温度下，用二甲基亚砜、二甲基乙酰胺、二甲基甲酰胺、甲酰胺、二氧六环或原甲酸甲酯预处理愈伤组织膜对沙林渗透性的影响，以确定运输的活化能。此外，还研究了膜预处理对通过来自沙林-羧基聚亚甲基凝胶或沙林-聚甲基丙烯酸甲酯凝胶的愈伤组织膜的渗透性的影响。