Sammett D, Lee E W, Kocsis J J, Snyder R
J Toxicol Environ Health. 1979 Sep;5(5):785-92. doi: 10.1080/15287397909529789.
Removal of 70--80% of the liver reduced both the metabolism and the toxicity of benzene in rats. Metabolism was evaluated by measuring the levels of urinary metabolites in both sham-operated and partially hepatectomized rats given 2200 mg/kg [3H]benzene sc. Toxicity was evaluated by measuring the incorporation of 59Fe into circulating erythrocytes according to the method of Lee et al. The observation that partial hepatectomy decreases benzene metabolism and protects against benzene toxicity indicates that the liver may play a primary role in the development of benzene-induced bone marrow toxicity. The fact that benzene administration also reduces the ability of the liver to regenerate after partial hepatectomy suggests that the regenerating liver may serve as a model system in lieu of the bone marrow for studying the mechanism by which benzene inhibits cell proliferation.
切除大鼠70%至80%的肝脏可降低苯在大鼠体内的代谢及毒性。代谢情况通过测量假手术组和部分肝切除术后经皮下注射2200 mg/kg [³H]苯的大鼠尿液代谢物水平来评估。毒性通过按照Lee等人的方法测量59Fe掺入循环红细胞的情况来评估。部分肝切除可降低苯代谢并预防苯毒性这一观察结果表明，肝脏可能在苯诱导的骨髓毒性发展中起主要作用。苯给药也会降低部分肝切除术后肝脏的再生能力，这一事实表明，再生肝脏可作为替代骨髓的模型系统，用于研究苯抑制细胞增殖的机制。
