Wills M R, Lewin M R
J Clin Pathol. 1971 Dec;24(9):856-66. doi: 10.1136/jcp.24.9.856.
A study is reported of the estimation of plasma calcium fractions and the calcium-binding affinity of plasma proteins in a total sample of 59 people, which included 29 normal subjects and 30 patients with either hypercalcaemia or hypocalcaemia. It was demonstrated that when the sample was considered as a whole there was a significant correlation between the total plasma calcium concentration and the ultrafiltrable, ionized, and protein-bound calcium fractions and between the ultrafiltrable and ionized fractions. We have also demonstrated that in patients with either hypercalcaemia or hypocalcaemia, including acidotic uraemics, the calcium-binding affinity of the plasma proteins did not differ significantly from that in normal subjects. A significant correlation was also found between the total plasma calcium concentration and the ultrafiltrable, ionized and protein-bound calcium fractions when the normal subjects and the groups of patients with hypercalcaemia and hypocalcaemia due to chronic renal failure were considered as separate groups. The group of patients with hypercalcaemia included patients both with hyperparathyroidism and with hypercalcaemia due to other causes.
本文报道了一项针对59人的全血样本进行血浆钙组分及血浆蛋白钙结合亲和力评估的研究。该样本包括29名正常受试者以及30名高钙血症或低钙血症患者。结果表明，将样本整体考虑时，血浆总钙浓度与超滤性钙、离子化钙及蛋白结合钙组分之间，以及超滤性钙与离子化钙组分之间均存在显著相关性。我们还证实，在高钙血症或低钙血症患者（包括酸中毒尿毒症患者）中，血浆蛋白的钙结合亲和力与正常受试者相比并无显著差异。当将正常受试者以及因慢性肾衰竭导致高钙血症和低钙血症的患者组分别视为独立组时，血浆总钙浓度与超滤性钙、离子化钙及蛋白结合钙组分之间也存在显著相关性。高钙血症患者组包括甲状旁腺功能亢进患者以及其他原因导致高钙血症的患者。
