[肾上腺素和胰岛素对氧化磷酸化的调节，胰岛素依赖性细胞质因子的作用]
[Regulation of oxidative phosphorylation by adrenaline and insulin, effect of the insulin-dependent cytoplasmic factor].
作者信息
Uzssr A N, Turakulov Ia Kh, Gaĭnutdinov M Kh, Lavina I I, Akhmatov M S
出版信息
Biull Eksp Biol Med. 1979 Sep;88(9):301-4.
The insulin-dependent cytoplasmic factor-regulator (IDR) was shown to inhibit pyruvate and succinate oxidation by the rat liver mitochondria. In view of the fact that insulin increases and adrenaline decreases IDR activity in the liver cytoplasm it is suggested that oxidation of the substrate in mitochondria in vivo is regulated by changes in IDR content in cytoplasm. It was shown that adrenaline-activated oxidation apart from decreased activity of IDR in cytoplasm is induced by a different mechanism not related to IDR content.
胰岛素依赖性细胞质因子调节蛋白（IDR）被证明可抑制大鼠肝脏线粒体中丙酮酸和琥珀酸的氧化。鉴于胰岛素会增加而肾上腺素会降低肝脏细胞质中IDR的活性，因此有人提出，体内线粒体中底物的氧化是由细胞质中IDR含量的变化来调节的。结果表明，肾上腺素激活的氧化作用，除了细胞质中IDR活性降低外，是由一种与IDR含量无关的不同机制所诱导的。
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