Schönbörner A A, Boivin G, Baud C A
Cell Tissue Res. 1979 Nov;202(2):203-12. doi: 10.1007/BF00232235.
In Teleost fish scales, growth and mineralization are continuous. Different mineralization processes can be distinguished. The external layer of the scale is the first to be mineralized and may be classified as the initial calcifying structure of the scale. The initial calcification loci are matrix vesicles of cellular origin always observed during the formation of this layer. This mineralization process takes place progressively, closely following the elaboration of the organic matrix in the scale periphery. The outer limiting and internal layers of the scale are developed after the external layer has been formed. A mineral substance is deposited without the mediation of matrix vesicles, but in contact with the previously mineralized external layer. This type of mineralization is called subsequential. However, the mineralization of the outer limiting layer closely follows the secretion of a collagen-free organic matrix and is thus different from the mineralization of the internal layer in which the calcification front remains remote from the collagen matrix surface and corresponds to a delayed mineralization process. The isolated calcifications (Mandl's corpuscles) which develop in the unmineralized laminae of the internal layer are mineralized in the absence of matrix vesicles and without making contact with a pre-existing calcified tissue, probably by a heterogeneous nucleation of the collagen fibrils.
在硬骨鱼类的鳞片中，生长和矿化是持续进行的。可以区分出不同的矿化过程。鳞片的外层是最先矿化的，可被归类为鳞片的初始钙化结构。初始钙化位点是细胞起源的基质小泡，在这一层形成过程中总能观察到。这种矿化过程是逐步发生的，紧密跟随鳞片周边有机基质的形成。鳞片的外部界限层和内层是在外部层形成之后发育的。一种矿物质在没有基质小泡介导的情况下沉积，但与先前矿化的外层接触。这种矿化类型称为后续矿化。然而，外部界限层的矿化紧密跟随无胶原有机基质的分泌，因此与内层的矿化不同，在内层中钙化前沿远离胶原基质表面，对应于一个延迟的矿化过程。在内层未矿化薄片中形成的孤立钙化（曼德尔小体）在没有基质小泡且不与预先存在的钙化组织接触的情况下矿化，可能是通过胶原纤维的异相成核作用。
