Reuther P, Wiebecke D, Hertel G, Böske A, Mertens H G
Dtsch Med Wochenschr. 1979 Dec 21;104(51):1806-10. doi: 10.1055/s-0028-1129195.
Nine out of eleven severely ill patients with myasthenia gravis could be markedly improved by a combination of immunosuppressive drug therapy and plasmapheresis, two patients however suffered grave complications. The effectiveness of plasma exchange underlines the importance of plasma factors in the pathomechanism of myasthenic functional disturbance. Treatment with plasmapheresis may be regarded as a supportive measure of immunosuppressive drug therapy. However, the considerable risk and high technical requirements limit the indication to severe forms of the disease.
11例重症肌无力患者中,9例通过免疫抑制药物治疗和血浆置换联合治疗后病情显著改善,但有2例出现严重并发症。血浆置换的有效性凸显了血浆因子在重症肌无力功能障碍发病机制中的重要性。血浆置换治疗可被视为免疫抑制药物治疗的一种支持性措施。然而,其相当大的风险和高技术要求使得该治疗仅适用于重症患者。