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在回避训练期间对边缘系统生化变化的放射自显影显示。

Autoradiographic demonstration of biochemical changes in the limbic system during avoidance training.

作者信息

Beach G, Emmens M, Kimble D P, Lickey M

出版信息

Proc Natl Acad Sci U S A. 1969 Mar;62(3):692-6. doi: 10.1073/pnas.62.3.692.

DOI:10.1073/pnas.62.3.692
PMID:5256997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC223653/
Abstract

After injection of leucine-H(3), members from eight triplets of rats were assigned to one of three treatment groups: avoidance learning, the same handling and shocks without opportunity to learn, or passive control. Autoradiographic grains over all nuclei were counted "blind." In the hippocampus, the number of grains for the learning rats was reliably greater than that for either control. The differences approached statistical significance in the entorhinal cortex and the septal area but not in other brain areas or in the liver. Although the processes responsible for the increased incorporation are not yet defined, these changes probably are the result of learning rather than of stress.

摘要

注射亮氨酸 - H(3) 后,将八组三联体大鼠中的成员分配到三个治疗组之一:回避学习组、接受相同处理和电击但无学习机会组或被动对照组。对所有细胞核上的放射自显影颗粒进行“盲法”计数。在海马体中,学习组大鼠的颗粒数量确实比两个对照组都多。在内嗅皮质和隔区,差异接近统计学意义,但在其他脑区或肝脏中则不然。尽管导致掺入增加的过程尚未明确,但这些变化可能是学习的结果而非应激的结果。

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Role of RNA and protein in memory storage: a review.RNA与蛋白质在记忆存储中的作用:综述
Behav Genet. 1974 Mar;4(1):29-81. doi: 10.1007/BF01066705.
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A physiological difference in the hippocampus of rats with a low inborn learning ability.天生学习能力较低的大鼠海马体中的生理差异。
Psychopharmacologia. 1972;23(4):386-96. doi: 10.1007/BF00406741.
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The neurochemistry of learning and memory.学习与记忆的神经化学
Environ Health Perspect. 1978 Oct;26:143-7. doi: 10.1289/ehp.7826143.

本文引用的文献

1
DIFFERENCES IN THE UTILIZATION OF TRITIATED LEUCINE BY SINGLE NEURONES IN NORMAL AND EXERCISED RATS: AN AUTORADIOGRAPHIC INVESTIGATION WITH MICRODENSITOMETRY.正常大鼠和运动大鼠单个神经元对氚标记亮氨酸利用的差异:一项采用显微密度计的放射自显影研究
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Protein metabolism in the nervous system.神经系统中的蛋白质代谢
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Functional significance of corticohippocampal connections.皮质-海马连接的功能意义。
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Effects of coping responses on stress.应对反应对压力的影响。
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Protein synthesis in the hippocampal pyramidal cells of rats during a behavioral test.行为测试期间大鼠海马锥体细胞中的蛋白质合成
Science. 1968 Mar 22;159(3821):1370-3. doi: 10.1126/science.159.3821.1370.
7
Brain function and macromolecules, IV. Uridine incorporation into polysomes of mouse brain during different behavioral experiences.脑功能与大分子,IV。不同行为经历期间尿苷掺入小鼠脑多核糖体的情况。
Proc Natl Acad Sci U S A. 1968 Nov;61(3):917-22. doi: 10.1073/pnas.61.3.917.
8
Brain function and macromolecules. II. Site of increased labeling of RNA in brains of mice during a short-term training experience.脑功能与大分子。II. 短期训练期间小鼠脑内RNA标记增加的部位
Proc Natl Acad Sci U S A. 1967 Sep;58(3):1120-5. doi: 10.1073/pnas.58.3.1120.
9
Brain function and macromolecules. I. Incorporation of uridine into RNA of mouse brain during short-term training experience.脑功能与大分子。I. 短期训练期间尿苷掺入小鼠脑RNA的情况。
Proc Natl Acad Sci U S A. 1966 Jun;55(6):1423-31. doi: 10.1073/pnas.55.6.1423.
10
The hippocampus and behavior.海马体与行为。
Psychol Bull. 1967 Jun;67(6):416-22. doi: 10.1037/h0024599.