Thillard M J
Ann Anat Pathol (Paris). 1979;24(2):149-60.
It is possible to make an early diagnosis of rat " op " osteopetrosis. The growth of the mandibular incisor is stopped at birth by failure of bone resorption around the dental root. The primary trabeculae of the long bones fail to undergo resorption: osteoblasts differentiate along them, but osteoclasts are missing and reticular cells are not distinguishable. When 2 and 3 days old, the medullary cavity is obstructed by osseous trabeculae, vascular system is lacking, hemopoietic cells no longer differentiate, osteoclasts are scarce and degenerative; medullary tissue is compact, including numerous osteoblastic cells. Bone marrow smears clearly show medullary cell deficiency, weakening hemopoiesis, prevalent osteoblasts and a lack of osteoclasts. Marrow is taken out "in vivo" from an excised metatarsal bone, at birth and over the next few days. Osteopetrotic rats identified in this way in litters issued from heterozygote pair can be treated from the first week.
大鼠“op”型骨质石化症有可能进行早期诊断。下颌切牙的生长在出生时因牙根周围骨吸收失败而停止。长骨的初级小梁未能进行吸收：成骨细胞沿小梁分化，但破骨细胞缺失且网状细胞无法区分。在2至3日龄时，骨髓腔被骨小梁阻塞，缺乏血管系统，造血细胞不再分化，破骨细胞稀少且退化；骨髓组织致密，包括大量成骨细胞。骨髓涂片清楚地显示骨髓细胞缺乏、造血功能减弱、成骨细胞占优势且破骨细胞缺乏。在出生时及接下来的几天内，从切除的跖骨“体内”取出骨髓。通过这种方式在杂合子配对产生的一窝幼崽中鉴定出的骨质石化症大鼠可从第一周开始治疗。
