Müller-Ruchholtz E R, Grund E, Hauer F, Lapp E R
Basic Res Cardiol. 1979 Sep-Oct;74(5):467-76. doi: 10.1007/BF01907641.
In 9 mongrel dogs, venous return was completely drained from the caval veins to an oxygenator and returned to the femoral arteries with a roller pump. Perfusion rate of systemic circulation and blood pressures in both caval veins were kept constant. Changes in the oxygenator weight were recorded and reflected reciprocal changes in integrated systemic venous blood volume. The vagal nerves were dissected. The carotid sinuses were separately perfused with blood by means of a pump. In 25 experiments, increases in carotid sinus pressure of 15 to 74 mm Hg resulted in decreases in systemic arterial pressure of 10 to 57 mm Hg and increases in systemic venous blood volume of 1.1 to 4.7 ml/kg. On an average, systemic venous blood volume was changed by 1.25 +/- 0.08 ml/kg when the change in systemic arterial pressure was 10 mm Hg. It is concluded that the carotid sinus pressoreceptor reflex considerably alters the systemic venous capacity which in tern alters venous return and cardiac output. These changes in cardiac output are expected to be small, but sufficient to alter the arterial pressure considerably. Thus, they might contribute nearly as much as the reflex effect on total peripheral resistance to the reflex control of arterial pressure.
在9只杂种狗身上，腔静脉的静脉回流通过一个氧合器完全引出，再用一个滚压泵将其回输至股动脉。体循环灌注率和两条腔静脉的血压保持恒定。记录氧合器重量的变化，其反映了体循环静脉血总量的相应变化。解剖迷走神经。通过一个泵分别向颈动脉窦灌注血液。在25次实验中，颈动脉窦压力升高15至74毫米汞柱导致体循环动脉压下降10至57毫米汞柱，体循环静脉血容量增加1.1至4.7毫升/千克。平均而言，当体循环动脉压变化10毫米汞柱时，体循环静脉血容量变化1.25±0.08毫升/千克。得出的结论是，颈动脉窦压力感受器反射会显著改变体循环静脉容量，进而改变静脉回流和心输出量。预计心输出量的这些变化很小，但足以显著改变动脉压。因此，它们对动脉压反射性控制的作用可能几乎与对总外周阻力的反射作用一样大。
