Mitchell C E, Tu K W
J Toxicol Environ Health. 1979 Nov;5(6):1171-9. doi: 10.1080/15287397909529822.
Pyrene was measured in tissues of Fischer 344 rats are various times after inhalation of pyrene aerosols (500 microgram/l; mass median diameter, 0.3-0., micrometer) for 1 h. Significant quantities of pyrene were found in nasal turbinates, trachea, lungs, kidney, and liver immediately after exposure. Clearance from the respiratory tract was rapid; concentrations in the trachea and lungs 48 h after exposure were 20 and 5% of the concentrations present 1/2 h after exposure. Pyrene also cleared from liver and kidney at a relatively rapid rate; concentrations in these tissues 48 h after exposure were approximately 10% of those 1/2 h after exposure. Concentrations in the gastrointestinal tract 24 h after exposure were 4 times those found 1/2 h after exposure. Pyrene cleared from the gastrointestinal tract approximately 4 d after exposure. Thus, inhaled pyrene is rapidly cleared from the respiratory tract by mucocilliary action from the trachea and bronchi and by translocation from the respiratory tract to the liver and kidney; it is eliminated primarily through the gastrointestinal tract.
在给予Fischer 344大鼠吸入芘气雾剂（500微克/升；质量中值直径，0.3 - 0.5微米）1小时后的不同时间，测定其组织中的芘含量。暴露后立即在鼻甲、气管、肺、肾和肝脏中发现大量芘。呼吸道清除迅速；暴露后48小时气管和肺中的浓度分别为暴露后半小时时浓度的20%和5%。芘也以相对较快的速度从肝脏和肾脏清除；暴露后48小时这些组织中的浓度约为暴露后半小时时的10%。暴露后24小时胃肠道中的浓度是暴露后半小时时的4倍。芘在暴露后约4天从胃肠道清除。因此，吸入的芘通过气管和支气管的黏液纤毛作用以及从呼吸道向肝脏和肾脏的转运而迅速从呼吸道清除；它主要通过胃肠道消除。
