Gelpi A P
Bull World Health Organ. 1967;37(4):539-46.
A previous survey for glucose-6-phosphate dehydrogenase (G6PD) deficiency among the Saudi Arab population residing along the Persian Gulf perimeter revealed a high frequency of the enzyme defect among subjects from oasis areas. The investigation reported was undertaken to supplement the previous study using a screening test with the same reliability as the conventional Motulsky brilliant cresyl blue procedure, to measure enzyme activity with a colorimetric assay among a small group of Saudis, and to study the distribution of the sickling trait among the same population. The findings substantiated the earlier study, indicated a close correlation between the distribution of the sickling trait and the enzyme defect, revealed a striking association between the sickling trait and G6PD deficiency among oasis subjects, and revealed a broad range of enzyme activity among enzyme-deficient males.
此前针对居住在波斯湾周边地区的沙特阿拉伯人群进行的一项葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症调查显示,绿洲地区人群中该酶缺陷的发生率很高。本报告所进行的调查旨在补充先前的研究,采用一种与传统莫特尔斯基煌焦油蓝法可靠性相同的筛查试验,对一小部分沙特人进行比色法酶活性测定,并研究同一人群中镰状细胞性状的分布情况。研究结果证实了早期研究,表明镰状细胞性状分布与酶缺陷之间存在密切关联,揭示了绿洲地区受试者中镰状细胞性状与G6PD缺乏症之间存在显著关联,还揭示了酶缺乏男性中酶活性范围广泛。