通过拮抗变构效应剂对大肠杆菌氨甲酰磷酸合成酶活性的调控。
Control of the activity of Escherichia coli carbamoyl phosphate synthetase by antagonistic allosteric effectors.
作者信息
Piérard A
出版信息
Science. 1966 Dec 23;154(3756):1572-3. doi: 10.1126/science.154.3756.1572.
PMID:5332549
Abstract
The synthesis of carbamoyl phosphate required in both arginine and pyrimidine biosyntheses is carried out by a single enzyme in Escherichia coli. Opposed effects of pyrimidine nucleotides and of ornithine on the activity of the enzyme ensure a proper supply of carbamoyl phosphate according to the needs of the two biosynthetic sequences.
摘要
在大肠杆菌中，精氨酸和嘧啶生物合成所需的氨甲酰磷酸的合成由单一酶完成。嘧啶核苷酸和鸟氨酸对该酶活性具有相反作用，可确保根据两个生物合成序列的需求适当供应氨甲酰磷酸。
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