Metabolites of alanosine, an antitumor antibiotic.

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作者信息

Jayaram H N, Tyagi A K, Anandaraj S, Montgomery J A, Kelley J A, Kelley J, Adamson R H, Cooney D A

出版信息

Biochem Pharmacol. 1979 Dec 15;28(24):3551-66. doi: 10.1016/0006-2952(79)90400-3.

DOI:10.1016/0006-2952(79)90400-3

PMID:533558

Abstract

摘要

相似文献

Metabolites of alanosine, an antitumor antibiotic.

Biochem Pharmacol. 1979 Dec 15;28(24):3551-66. doi: 10.1016/0006-2952(79)90400-3.

Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase.肿瘤中L-丙氨菌素的抗代谢物L-丙氨酰-5-氨基-4-咪唑羧酸核糖核苷酸的鉴定及其对腺苷酸琥珀酸合成酶抑制作用的评估。

Cancer Res. 1980 Dec;40(12):4390-7.

Determination of L-alanosine in plasma and urine by reversed-phase high-performance liquid chromatography of the Dns derivative.通过丹磺酰氯（Dns）衍生物的反相高效液相色谱法测定血浆和尿液中的L-丙氨菌素。

J Chromatogr. 1979 Feb 11;170(1):195-201. doi: 10.1016/s0021-9673(00)84251-x.

Pharmacologic disposition of DL-alanosine in mice, rats, dogs, and monkeys.DL-丙氨酰核苷在小鼠、大鼠、狗和猴子体内的药物处置情况。

Cancer Treat Rep. 1977 Nov;61(8):1471-84.

Enzymatic release of nitric oxide from L-alanosine, an antineoplastic antibiotic.从抗肿瘤抗生素L-丙氨酸中酶促释放一氧化氮。

Biochem Biophys Res Commun. 1982 Mar 30;105(2):560-6. doi: 10.1016/0006-291x(82)91471-1.

Studies on the mechanism of resistance of selected murine tumors to L-alanosine.

Biochem Pharmacol. 1981 May 1;30(9):915-24. doi: 10.1016/0006-2952(81)90034-4.

Biochemical pharmacology, metabolism, and mechanism of action of L-alanosine, a novel, natural antitumor agent.新型天然抗肿瘤药物L-丙氨酰-L-丙氨酸的生化药理学、代谢及作用机制

Adv Pharmacol Chemother. 1984;20:69-121. doi: 10.1016/s1054-3589(08)60265-3.

Determinants of the toxicity of L-alanosine to various organs of the mouse.L-丙氨酰核苷对小鼠各器官毒性的决定因素。

Toxicology. 1981;21(1):59-69. doi: 10.1016/0300-483x(81)90016-0.

Binding of copper and zinc by the antitumour agent L-alanosine.

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L-alanosine: a noncooperative substrate for Escherichia coli aspartate transcarbamylase.L-丙氨菌素：大肠杆菌天冬氨酸转氨甲酰酶的一种非协同底物。

Biochemistry. 1985 Dec 3;24(25):7182-7. doi: 10.1021/bi00346a025.

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Contragestational profile of the tumor-inhibiting agent, L-alanosine, in the rat and the hamster.肿瘤抑制因子L-丙氨酰-核苷在大鼠和仓鼠中的抗孕作用概况。

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