Roy J C, Bilodeau M, Giroux M
Can Med Assoc J. 1967 Jun 3;96(22):1468-73.
This paper reports studies on different aspects of the administration of lincomycin by aerosol in dogs.The purpose of the study was to determine the depth of penetration of the drug into the lungs and its transfer into the blood, urine and tissues when administered as an aerosol.Special consideration was given to the possibility of side effects at the level of the bronchial mucosa, since this study was viewed as preliminary to the use of the antibiotic in humans.
本文报道了关于犬雾化吸入林可霉素不同方面的研究。该研究的目的是确定药物雾化吸入时在肺内的渗透深度以及其向血液、尿液和组织中的转移情况。由于该研究被视为该抗生素用于人类的前期研究,因此特别考虑了支气管黏膜层面出现副作用的可能性。