Spona J, Ulm R, Bieglmayer C, Husslein P
Gynecol Obstet Invest. 1979;10(2-3):71-80. doi: 10.1159/000299920.
Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (HPRL), 17 beta-estradiol (E2) and progesterone (P) were estimated in 46 subjects with normal menstrual cycles in whom hysterectomies were performed. Estrogen (ER) and progesterone receptor (PgR) levels in endometrial samples of these patients were estimated, and histological dating of the cycle day was carried out. Similarly, hormone serum levels and ER as well as PgR were estimated in 17 patients with endometrial carcinoma. No correlation between LH, FSH, HPRL and ER as well as PgR was noted in the normal subjects. Correlation between P and ER was observed in this group. Parallel variations between E2 and PgR were recorded in the normal females. In the carcinoma group no correlations between hormone serum levels and receptor contents were found, but ER and PgR correlated with each other. Receptor levels was highest in the well-differentiated group of endometrial carcinoma. The present experiments provide a rationale for progestagen therapy of carcinoma of the endometrium.
对46例月经周期正常且接受子宫切除术的受试者测定了血清促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（HPRL）、17β-雌二醇（E2）和孕酮（P）水平。测定了这些患者子宫内膜样本中的雌激素（ER）和孕激素受体（PgR）水平，并进行了周期日的组织学分期。同样，对17例子宫内膜癌患者测定了激素血清水平以及ER和PgR。在正常受试者中，未发现LH、FSH、HPRL与ER以及PgR之间存在相关性。在该组中观察到P与ER之间存在相关性。在正常女性中记录到E2与PgR之间存在平行变化。在癌组中，未发现激素血清水平与受体含量之间存在相关性，但ER和PgR相互相关。受体水平在高分化子宫内膜癌组中最高。本实验为子宫内膜癌的孕激素治疗提供了理论依据。
