羟基化N-亚硝胺的气相色谱分离
Gas chromatographic separation of hydroxylated N-nitrosamines.
作者信息
Ohshima H, Matsui M, Kawabata T
出版信息
J Chromatogr. 1979 Feb 1;169:279-86. doi: 10.1016/0021-9673(75)85051-5.
PMID:536419
Abstract
Derivatives of six hydroxylated N-nitrosamines were prepared by acylation, trifluoroacylation, trimethylsilylation and methylation, and the volatilities and sensitivities of these derivatives on gas chromatographic detection were compared. All six nitrosamines were successfully derivatized by either acylation or trimethylsilylation. The acylated derivatives were easy to prepare; in addition, acylation was more specific than trimethylsilylation for the reaction with hydroxyl groups in the molecule.
摘要
通过酰化、三氟乙酰化、三甲基硅烷化和甲基化反应制备了六种羟基化N-亚硝胺的衍生物，并比较了这些衍生物在气相色谱检测中的挥发性和灵敏度。所有六种亚硝胺均通过酰化或三甲基硅烷化成功衍生化。酰化衍生物易于制备；此外，酰化反应在与分子中的羟基反应时比三甲基硅烷化更具特异性。
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