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“解毒性口渴”：对中毒的一种反应。

"Antidotal thirst": a response to intoxication.

作者信息

Smith D F, Balagura S, Lubran M

出版信息

Science. 1970 Jan 16;167(3916):297-8. doi: 10.1126/science.167.3916.297.

DOI:10.1126/science.167.3916.297
PMID:5409712
Abstract

Albino rats increased their intake of water soon after they were given a load of 0.12 molar lithium chloride in the stomach. Alterations in blood volume and tonicity could not account for the magnitude of the thirst observed, which served to facilitate the renal excretion of the toxic lithium ions.

摘要

给白化大鼠胃内灌入0.12摩尔的氯化锂后不久，它们的饮水量就增加了。血容量和张力的改变无法解释所观察到的口渴程度，而口渴有助于肾脏排出有毒的锂离子。

相似文献

1
"Antidotal thirst": a response to intoxication.“解毒性口渴”：对中毒的一种反应。
Science. 1970 Jan 16;167(3916):297-8. doi: 10.1126/science.167.3916.297.
2
Antidotal thirst and lithium excretion in rats with hypothalamic lesions.
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Restoration of intravascular fluid volume following acute hypovolemia in rats.大鼠急性低血容量后血管内容量的恢复
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Voluntary lithium intake, antidotal thirst' and concurrent behavior of rats.大鼠的自愿锂摄入、解毒性口渴及并发行为。
Br J Pharmacol. 1975 Nov;55(3):409-13. doi: 10.1111/j.1476-5381.1975.tb06945.x.
8
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Inhibition of nitric oxide synthase attenuates osmotic thirst in the rat.一氧化氮合酶的抑制可减轻大鼠的渗透性口渴。
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引用本文的文献

1
On the mechanism of lithium-induced diabetes insipidus in man and the rat.关于锂诱发人类和大鼠尿崩症的机制。
J Clin Invest. 1974 Apr;53(4):1115-23. doi: 10.1172/JCI107649.
2
Inhibition by lithium of the hydroosmotic action of vasopressin in the isolated perfused cortical collecting tubule of the rabbit.锂对家兔离体灌注皮质集合管中血管升压素水渗透作用的抑制
J Clin Invest. 1986 May;77(5):1507-14. doi: 10.1172/JCI112465.
3
Voluntary lithium intake, antidotal thirst' and concurrent behavior of rats.大鼠的自愿锂摄入、解毒性口渴及并发行为。
Br J Pharmacol. 1975 Nov;55(3):409-13. doi: 10.1111/j.1476-5381.1975.tb06945.x.
4
Time course of lithium-induced alterations in renal and endocrine function in normal and Brattleboro rats with hypothalamic diabetes insipidus.正常大鼠和患有下丘脑性尿崩症的布拉特洛维大鼠中锂诱导的肾脏和内分泌功能改变的时间进程。
Br J Pharmacol. 1977 Apr;59(4):627-34. doi: 10.1111/j.1476-5381.1977.tb07731.x.