Gee M H, Donovan K A
Lymphology. 1979 Sep;12(3):125-32.
In animals with edema, pulmonary and systemic lymphatics may function to remove accumulated extravascular fluid in addition to responding to events as they occur in the exchanging vessels. We tested this hypothesis by measuring the flow rate and composition of thoracic duct and right duct lymph in anesthetized dogs made edematous by rapid fluid infusion. During a fluid challenge equivalent to 30% of body weight, thoracic and right duct lymph flow rates increased 30- and 60-fold, respectively. After the infusion, lymph flow rates rapidly decreased even though the dogs were edematous. During the postinfusion period, the decrease in right duct lymph flow rate was directly related to a decrease in estimated net pulmonary fluid filtration pressure. We conclude that lymph flow rate and composition reflect events occurring in the microvasculature whether or not edema is present.
在患有水肿的动物中，除了对交换血管中发生的事件做出反应外，肺和全身淋巴管还可能起到清除血管外积聚液体的作用。我们通过测量快速输液致麻醉犬水肿后胸导管和右导管淋巴的流速及成分，对这一假设进行了验证。在相当于体重30%的液体冲击期间，胸导管和右导管淋巴流速分别增加了30倍和60倍。输液后，尽管犬仍处于水肿状态，但淋巴流速迅速下降。在输液后阶段，右导管淋巴流速的下降与估计的肺净液体滤过压的下降直接相关。我们得出结论，无论是否存在水肿，淋巴流速和成分都反映了微血管系统中发生的事件。
