Vickers T H
Br J Exp Pathol. 1970 Jun;51(3):286-97.
Among 906 thalidomide exposed young from 6 different rabbit strains, 141 major malformations involving the alimentary tract were found. All but 4 of the defects can confidently be regarded as a drug effect. The lesions occurred in the derivatives of the foregut, hindgut and umbilicus. Foregut anomalies (68 specimens) comprised hiatus hernia, megaoesophagus, prepyloric notching of the greater curvature of the stomach and deficient septum formation between oesophagus and trachea. In many rabbits all 4 lesions were present together. Hindgut malformations (61 specimens) were made up of rectal atresia and a small number of diverticula and/or saccular dilatations of the terminal colon, some in company with atresia. The 32 examples of atresia which were examined in detail had a coexistent fistula extending to the urethra or the anus. Omphalocoele (6 specimens in one strain) was the umbilical defect. It is suggested that some of the lesions result from impeded septum formation in the laryngotracheal grouve and the cloaca.
在来自6种不同兔种的906只接触沙利度胺的幼兔中，发现了141例涉及消化道的严重畸形。除4例缺陷外，其余均可确定为药物作用所致。这些病变发生在前肠、后肠和脐的衍生物中。前肠异常（68例标本）包括食管裂孔疝、巨食管、胃大弯处幽门前切迹以及食管与气管之间的隔膜形成缺陷。在许多兔子中，这4种病变同时存在。后肠畸形（61例标本）由直肠闭锁以及少数末端结肠憩室和/或囊状扩张组成，有些伴有闭锁。对详细检查的32例闭锁病例进行分析，发现均伴有延伸至尿道或肛门的瘘管。脐膨出（一个兔种中有6例标本）是脐部缺陷。有人认为，某些病变是由于喉气管沟和泄殖腔中隔膜形成受阻所致。
