Windsor A C, Williams C B
Br Med J. 1970 Mar 21;1(5698):732-3. doi: 10.1136/bmj.1.5698.732.
Fourteen elderly patients aged 58 to 91 with varying leucocyte ascorbic acid levels had urinary hydroxyproline/creatinine ratios measured before, during, and after treatment with ascorbic acid 1 g. daily for six days. The ratio increased during treatment in those patients whose initial ascorbic acid levels were below 15mug./10(8) white blood cells. It is suggested that collagen metabolism may be impaired in these patients, and that all such patients should receive ascorbic acid supplements.
14名年龄在58至91岁之间、白细胞中维生素C水平各异的老年患者，在每日服用1克维生素C，持续六天的治疗前、治疗期间和治疗后，测量了尿羟脯氨酸/肌酐比值。在初始维生素C水平低于15微克/10⁸白细胞的患者中，该比值在治疗期间有所增加。提示这些患者的胶原代谢可能受损，所有此类患者均应补充维生素C。
