Solter D, Dominis M, Damjanov I
Int J Cancer. 1979 Dec 15;24(6):770-2. doi: 10.1002/ijc.2910240612.
The role of gender and genetic (strain-specific) factors in the regulation of teratocarcinogenesis was studied by monitoring the outgrowth of benign and malignant embryo-derived teratoid tumors, i.e., teratomas and teratocarconomas in several mouse strains. Teratocarcinomas were produced in all mouse strains tested, but the ratio of teratoma to teratocarcinoma varied from one strain to another. A high yield of teratocarcinomas was obtained in A/J, BALB/cJ, DBA/2J, CBA/J and C3H/J mice, irrespective of the sex of the recipient. A low yield of teratocarcinomas was obtained in both male and female C57BL/6J and AKR/J recipients, and in 129/J female recipients. For all strains but 129/J and eventually AKR/J the sex of the recipients did not significantly affect the outgrowth of embryo-derived tumors. These data suggest the existence of mouse strains with high and low permissiveness for embryo-derived teratocarcinogenesis. The sex of the recipients may influence the yield of embryo-derived teratocarcinomas in some mouse strains but is of no consequence in others.
通过监测几种小鼠品系中良性和恶性胚胎源性畸胎样肿瘤（即畸胎瘤和畸胎癌）的生长情况，研究了性别和遗传（品系特异性）因素在畸胎癌发生调控中的作用。在所测试的所有小鼠品系中均产生了畸胎癌，但畸胎瘤与畸胎癌的比例因品系而异。在A/J、BALB/cJ、DBA/2J、CBA/J和C3H/J小鼠中，无论受体性别如何，畸胎癌的产量都很高。在雄性和雌性C57BL/6J和AKR/J受体以及129/J雌性受体中，畸胎癌的产量较低。对于除129/J以及最终的AKR/J之外的所有品系，受体的性别对胚胎源性肿瘤的生长没有显著影响。这些数据表明存在对胚胎源性畸胎癌发生具有高易感性和低易感性的小鼠品系。受体的性别可能会影响某些小鼠品系中胚胎源性畸胎癌的产量，但对其他品系则没有影响。
