两种热带海生环节动物触手对小鼠的抗肿瘤活性。
Antitumor activity in mice of tentacles of 2 tropical sea annelids.
作者信息
Tabrah F L, Kashiwagi M, Norton T R
出版信息
Science. 1970 Oct 9;170(3954):181-3. doi: 10.1126/science.170.3954.181.
PMID:5456611
Abstract
Crude extracts of tentacles of two polychaetous annelids completely inhibit growth of Erlich ascites tumor in 60 to 100 percent of treated mice. Dialyzed extracts of one of these annelids, Lanice conchilega, show activity in the retentate after pronase digestion, suggesting that antitumor activity is associated with a nonprotein component of the crude tentacle extract.
摘要
两种多毛纲环节动物触手的粗提取物能使60%至100%接受治疗的小鼠体内的艾氏腹水瘤生长完全受到抑制。其中一种环节动物，即兰氏蛰龙介，经透析后的提取物在经链霉蛋白酶消化后的保留物中显示出活性，这表明抗肿瘤活性与触手粗提取物的一种非蛋白质成分有关。
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