Determination of unchanged hydralazine in plasma by gas-liquid chromatography using nitrogen-specific detection.
作者信息
Degen P H
出版信息
J Chromatogr. 1979 Sep 1;176(3):375-80. doi: 10.1016/s0021-9673(00)89455-8.
PMID:546921
Abstract
A gas chromatographic method is described for the specific determination of unchanged hydralazine in plasma. On treatment with 2,4-pentanedione, hydralazine is converted into 1-(3,5-dimethyl-1-pyrazolyl)phthalazine, a stable compound which is easily extracted from biological material and determined quantitatively by gas chromatography with nitrogen-specific detection. 4-Methylhydralazine is used as an internal standard. The sensitivity of the method is ca. 10 ng/ml. Hydrazones of hydralazine do not interfere with the assay.
摘要
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