Some structure-activity relationships of iodophorous iodine complex compounds. Part I. Chemistry.

Five nonionic tensides of a general formula 4-R-C6H4O(CH2CH2O)nCH2CH2OH were prepared by modifying in their structure the nature of the substituent in phenyl group and the length of the ethyleneglycol polycondensate linked with the oxygen of the phenol rest. From the tensides obtained in this way appropriate complexes of iodophorous character were prepared by treating them with iodine solution in hydroiodic acid. Using 131I it was possible to obtain complexes labelled with 131I. This in turn enabled us to determine the degree of iodine complexing in the iodophor solutions by means of a radiometric method.