孕期长期使用吲哚美辛进行安胎治疗的围产期风险。

Perinatal hazards of chronic antenatal tocolysis with indomethacin.

作者信息

Van Kets H, Thiery M, Derom R, Van Egmond H, Baele G

出版信息

Prostaglandins. 1979 Dec;18(6):893-907. doi: 10.1016/0090-6980(79)90126-6.

Abstract

Indomethacin was administered from the 20th to the 34th week of gestation to 51 women (59 fetuses) in whom bed rest and a beta-mimetic compound (ritodrine) had failed to stop preterm labor. No serious maternal side effects were observed. Of the 8 perinatal deaths, 5 were not and 3 were possibly related to the prostaglandin synthesis inhibitor. The sole case of serious neonatal morbidity is not considered to have had a causal relationship with the indomethacin treatment.

摘要

对51名妇女（59例胎儿）在妊娠第20周至34周期间使用了吲哚美辛，这些妇女卧床休息并用β-拟交感神经化合物（利托君）均未能阻止早产。未观察到严重的母体副作用。在8例围产期死亡病例中，5例与吲哚美辛无关，3例可能与前列腺素合成抑制剂有关。仅有的1例严重新生儿发病病例不被认为与吲哚美辛治疗有因果关系。