Rae P G, Robb P M
J Clin Pathol. 1970 Jul;23(5):379-91. doi: 10.1136/jcp.23.5.379.
It has been shown that the incidence of megaloblastic anaemia in a group of 463 randomly selected pregnant women receiving iron was 12 times as high as in a control group of 235 pregnant women receiving iron and folic acid. The incidence of all types of anaemia in the women receiving iron alone was more than three times the incidence in those having iron and folic acid. Some women who were not anaemic or who had normoblastic anaemia had serum folate levels in the same range as the women with megaloblastic anaemia, but none of the women with megaloblastic anaemia had high serum folate levels. The labile fraction of the serum folate was no more reliable than the total serum folate as a diagnostic criterion of megaloblastic erythropoiesis in the individual case. The blood group distribution in the women with megaloblastic anaemia was the same as in the general population. Babies born to mothers with megaloblastic anaemia tended to be smaller than the rest, although there was no difference in the placental weights. The significance of these findings is discussed.
研究表明，在一组463名随机选取的接受铁剂治疗的孕妇中，巨幼细胞贫血的发病率是另一组235名接受铁剂和叶酸治疗的孕妇对照组的12倍。仅接受铁剂治疗的女性中各类贫血的发病率是同时接受铁剂和叶酸治疗女性的三倍多。一些未患贫血或患正常幼红细胞贫血的女性，其血清叶酸水平与患巨幼细胞贫血的女性处于同一范围，但患巨幼细胞贫血的女性中没有血清叶酸水平高的。在个别病例中，血清叶酸的不稳定部分作为巨幼细胞性红细胞生成的诊断标准并不比总血清叶酸更可靠。患巨幼细胞贫血的女性的血型分布与一般人群相同。患巨幼细胞贫血的母亲所生婴儿往往比其他婴儿小，尽管胎盘重量没有差异。文中对这些发现的意义进行了讨论。
