帕金森病：不同脑区中左旋多巴脱羧酶的活性
Parkinson's disease: activity of L-dopa decarboxylase in discrete brain regions.
作者信息
Lloyd K, Hornykiewicz O
出版信息
Science. 1970 Dec 11;170(3963):1212-3. doi: 10.1126/science.170.3963.1212.
PMID:5478194
Abstract
The activity of L-dopa decarboxylase was greatly reduced in the striatum, less so in the hypothalamus, and unchanged in the cortex of brains of patients with Parkinson's disease. However, it appears that even in the striatum enough activity remained to allow for the formation of dopamine from L-dopa in patients treated with large doses of L-dopa.
摘要
在帕金森病患者的大脑中，纹状体中左旋多巴脱羧酶的活性大幅降低，下丘脑的活性降低程度较小，而皮质中的活性则无变化。然而，似乎即使在纹状体中，对于接受大剂量左旋多巴治疗的患者而言，仍保留了足够的活性以使得左旋多巴能够形成多巴胺。
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