胸腺衍生淋巴细胞的分化研究。
Studies on the differentiation of thymus-derived lymphocytes.
作者信息
Owen J J, Raff M C
出版信息
J Exp Med. 1970 Dec 1;132(6):1216-32. doi: 10.1084/jem.132.6.1216.
Abstract
The development pathway from embryonic thymus-stem cell to peripheral thymus-derived lymphocyte has been demonstrated using the alloantigens theta (theta) and TL as surface markers of cell differentiation. On the basis of cytotoxicity tests carried out on CBA.H or A embryo thymus cultured in diffusion chambers and on CBA.H embryo thymus grafts and peripheral lymphocytes derived from them in AKR hosts, it has been concluded that two differentiation stages take place during the maturation of thymus-derived cells, namely a first step from stem cell to thymocyte and a second step from thymocyte to peripheral lymphocyte.
摘要
利用同种异体抗原θ（theta）和TL作为细胞分化的表面标志物，已证明了从胚胎胸腺干细胞到外周胸腺衍生淋巴细胞的发育途径。基于对在扩散室中培养的CBA.H或A胚胎胸腺以及在AKR宿主中其CBA.H胚胎胸腺移植和外周淋巴细胞进行的细胞毒性试验，得出结论：胸腺衍生细胞成熟过程中发生两个分化阶段，即从干细胞到胸腺细胞的第一步和从胸腺细胞到外周淋巴细胞的第二步。
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