鼠伤寒沙门氏菌鞭毛蛋白的甲基化作用。
Methylation of the flagellin of Salmonella typhimurium.
作者信息
Tronick S R, Martinez R J
出版信息
J Bacteriol. 1971 Jan;105(1):211-9. doi: 10.1128/jb.105.1.211-219.1971.
Abstract
The methylation of endogenous proteins by Salmonella typhimurium SL 870 was investigated in cell-free extracts by using S-adenosylmethionine as methyl donor. Several lines of evidence are presented which suggest that one of the methylated products is the protein flagellin. Mutant strains of SL 870 (nml(-)fla(+) and nml(+)fla(-)) were also found to synthesize epsilon-N-methyl-lysine. It is proposed that S. typhimurium possesses at least two genes specifying different methylating enzymes. One gene product is a flagellin-specific methylating enzyme, whereas the other gene(s) codes for enzymes that methylate one or more other cell proteins.
摘要
利用S-腺苷甲硫氨酸作为甲基供体，在无细胞提取物中研究了鼠伤寒沙门氏菌SL 870对内源蛋白质的甲基化作用。提供了几条证据表明甲基化产物之一是蛋白质鞭毛蛋白。还发现SL 870的突变株（nml(-)fla(+)和nml(+)fla(-)）能合成ε-N-甲基赖氨酸。有人提出，鼠伤寒沙门氏菌至少拥有两个指定不同甲基化酶的基因。一种基因产物是鞭毛蛋白特异性甲基化酶，而另一个基因编码使一种或多种其他细胞蛋白质甲基化的酶。
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