伴有脑部病变的恶性三日疟治疗新观念。
New concepts in treatment of malignant tertian malaria with cerebral involvement.
作者信息
Smitskamp H, Wolthuis F H
出版信息
Br Med J. 1971 Mar 27;1(5751):714-6. doi: 10.1136/bmj.1.5751.714.
Abstract
Of 140 patients with malignant tertian malaria seen during 1956 to 1967 10 died. Death was caused by cerebral malaria in all cases. Since 1968 more intensified treatment has resulted in the complete recovery of three patients and the partial recovery of one, all of whom had been in a cerebral malaria coma for various periods of time before admission and in whom a fatal outcome was expected. In these cases a polypragmatic therapeutic approach using intravenous low molecular weight dextran, besides the usual quinine and fluids, corticosteroids, heparin and urea, separately or combined, was adopted.
摘要
1956年至1967年间诊治的140例恶性三日疟患者中，有10例死亡。所有病例的死亡均由脑型疟疾所致。自1968年起，采用了更强化的治疗方法，有3例患者完全康复，1例部分康复，所有这些患者在入院前均已处于脑型疟疾昏迷状态不同时间，原本预计会有致命结局。在这些病例中，除了常规使用的奎宁、补液、皮质类固醇、肝素和尿素外，还单独或联合采用了静脉输注低分子右旋糖酐的综合治疗方法。
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