Nielsen J, Homma A, Bertelsen A
Br J Psychiatry. 1977 Apr;130:352-4. doi: 10.1192/bjp.130.4.352.
Chromosome examination was made in 22 monozygotic and 27 dizygotic twin pairs of whom one or both of each pair suffered or had suffered from manic-depressive disorder. We found a significantly higher frequency of chromosome variations among dizygotic twin pairs than was expected from population studies, but not in monozygotic pairs. There was no association between the chromosome variations and manic-depressive disorders. We found no greater intra-pair correlation in monozygotic twins compared with dizygotic twins as regards hypodiploidy, hyperdiploidy and unstable chromosome aberrations, which indicates that the aetiology of such aberrations is mainly of exogenic nature.
对22对单卵双胞胎和27对双卵双胞胎进行了染色体检查，每对双胞胎中有一方或双方患有躁郁症。我们发现，双卵双胞胎对中染色体变异的频率显著高于人群研究预期，但单卵双胞胎对中并非如此。染色体变异与躁郁症之间没有关联。在亚二倍体、超二倍体和不稳定染色体畸变方面，我们发现单卵双胞胎与双卵双胞胎相比，双胞胎对内部的相关性并无更大差异，这表明此类畸变的病因主要是外源性的。
