葡萄球菌的耐药性。VI. 氯霉素耐药性的遗传决定因素。
Drug resistance of staphylococci. VI. Genetic determinant for chloramphenicol resistance.
作者信息
Kono M, Ogawa K, Mitsuhashi S
出版信息
J Bacteriol. 1968 Mar;95(3):886-92. doi: 10.1128/jb.95.3.886-892.1968.
Abstract
Naturally occurring strains of staphylococci which are resistant to chloramphenicol (CM) inactivate this antibiotic. One of the inactivation products of CM showed the chromatographic behavior of 3-acetoxychloramphenicol. Induction of resistance occurred after prior exposure to subinhibitory concentrations of the antibiotic. The resistance of induced populations, as well as CM-inactivation ability, was decreased when they were grown in CM-free medium. The CM-inactivation property was transduced together with CM resistance. Transductional analysis and CM-resistance elimination experiments indicated that CM resistance in naturally occurring strains of staphylococci is mainly accounted for by inactivation of the drug.
摘要
对氯霉素（CM）具有抗性的天然葡萄球菌菌株会使这种抗生素失活。CM的一种失活产物表现出3-乙酰氧基氯霉素的色谱行为。在预先暴露于亚抑制浓度的抗生素后会诱导产生抗性。当诱导群体在无CM的培养基中生长时，其抗性以及CM失活能力都会降低。CM失活特性与CM抗性一起被转导。转导分析和CM抗性消除实验表明，天然葡萄球菌菌株中的CM抗性主要是由药物失活引起的。
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