Harvey R B, Bassingthwaighte J B, Heppner R L
Clin Chem. 1968 Oct;14(10):944-59.
A method for controlling the plasma creatinine concentration is described. This method uses continuous determination of the plasma creatinine concentration and a servomechanism which drives an infusion pump at a rate proportional to the difference between the actual and desired creatinine concentrations. The rate and volume of creatinine infusion necessary to maintain the desired plasma concentration provide information related to kidney function and the accumulation of creatinine in the body. Experiments using this technic and the method of data analysis are described. It has been shown that under certain conditions this technic may be used to estimate the renal clearance of creatinine and the size and nature of the space into which creatinine is distributed in the dog.
描述了一种控制血浆肌酐浓度的方法。该方法采用连续测定血浆肌酐浓度,并通过一个伺服机构以与实际肌酐浓度和期望肌酐浓度之差成比例的速率驱动输液泵。维持期望血浆浓度所需的肌酐输注速率和体积提供了与肾功能及肌酐在体内蓄积相关的信息。描述了使用该技术及数据分析方法的实验。结果表明,在某些条件下,该技术可用于估计犬体内肌酐的肾清除率以及肌酐分布空间的大小和性质。