Luke R G, Kennedy A C, Briggs J D, Struthers N W, Stirlings W B
Br Med J. 1968 Sep 28;3(5621):764-8. doi: 10.1136/bmj.3.5621.764.
Nephrectomy has been carried out in 34 patients with hypertension associated with unilateral parenchymal renal disease (28 with unilateral pyelonephritis, 3 tuberculosis, 2 hypoplasia, and 1 adenocarcinoma). In 13 of the patients the blood pressure was corrected, in four it was improved, and in 17 it was unaffected. The intravenous pyelogram (by the infusion technique with nephrotomography if necessary) and renogram give adequate information in most patients with unilateral parenchymal renal disease but may need to be supplemented by aortography, or retrograde pyelography, or divided renal function studies in a few special circumstances. When the function of the damaged kidney is less than 25% of the total (which is well maintained), and the contralateral kidney is intact, nephrectomy is recommended provided the hypertension is significant; success is more likely in younger patients with a short history of hypertension.
对34例伴有单侧实质性肾病的高血压患者实施了肾切除术（其中28例为单侧肾盂肾炎，3例为结核，2例为发育不全，1例为腺癌）。13例患者的血压恢复正常，4例有所改善，17例未受影响。静脉肾盂造影（必要时采用静脉滴注技术并进行断层摄影）和肾图检查可为大多数单侧实质性肾病患者提供充分信息，但在少数特殊情况下可能需要辅以主动脉造影、逆行肾盂造影或分侧肾功能研究。当受损肾脏的功能低于总量的25%（总量保持良好）且对侧肾脏完好时，若高血压较为严重，则建议进行肾切除术；年轻且高血压病史较短的患者更有可能成功。
