Darrell J H, Garrod L P, Waterworth P M
J Clin Pathol. 1968 Mar;21(2):202-9. doi: 10.1136/jcp.21.2.202.
Trimethoprim is a synthetic compound which arrests the step in bacterial purine synthesis immediately succeeding that interfered with by sulphonamides. Acting alone it inhibits the growth of a wide range of bacteria in generally much lower concentrations than sulphonamides. Its action with a sulphonamide is strongly synergic and bactericidal.Studies are described of suitable cultural conditions, methods of testing sensitivity, and acquired resistance. Some clinical results of its use are reported in respiratory tract infections, Gram-negative septicaemia, and urinary tract infections, and further therapeutic possibilities are discussed.
甲氧苄啶是一种合成化合物，它能阻止细菌嘌呤合成过程中紧跟在被磺胺类药物干扰的步骤之后的那一步。单独使用时，它能抑制多种细菌的生长，其浓度通常比磺胺类药物低得多。它与磺胺类药物联合使用时具有很强的协同杀菌作用。文中描述了合适的培养条件、检测敏感性的方法以及获得性耐药性的研究。报告了其在呼吸道感染、革兰氏阴性菌败血症和尿路感染中的一些临床应用结果，并讨论了进一步的治疗可能性。
