Gladue B A, Clemens L G
Endocrinology. 1978 Nov;103(5):1702-9. doi: 10.1210/endo-103-5-1702.
The prenatal influence of androgen on the development of female sexual behavior in rats was investigated. The nonsteroidal antiandrogen, flutamide (4'-nitro-3'-trifluoromethylisobutyrylanilide; SCH), was administered to pregnant female rats from days 10--22 of gestation in dosages of either 1 mg/mother-day or 5 mg/mother-day. Males and females were gonadectomized in adulthood and tested for the display of lordosis in response to estradiol benzoate (EB) alone or EB with progesterone (P). Males exposed prenatally to either the 1- or 5-mg dosage of flutamide exhibited significantly higher lordosis quotients than controls when given EB alone. The addition of P was without effect in all male groups with regard to estrogen-induced lordosis. Females exposed prenatally to flutamide had significantly higher lordosis quotients than controls when given either 0.175 or 0.25 micrograms EB daily for 3 days. Addition of P to EB treatment significantly facilitated lordosis display in control and flutamide-treated females. The increase of feminine sexual behavior in both males and females of feminine sexual behavior in both males and females resulting from prenatal antiandrogen treatment suggests that androgen, prenatally, inhibits development of female sexual behavior. This androgenic inhibition of sexual receptivity (defeminization) seems to be related to the animal's sensitivity to estrogen in adulthood.
研究了雄激素对大鼠雌性性行为发育的产前影响。在妊娠第10至22天，给怀孕的雌性大鼠施用非甾体类抗雄激素氟他胺（4'-硝基-3'-三氟甲基异丁酰苯胺；SCH），剂量为1毫克/母·天或5毫克/母·天。成年后对雄性和雌性进行性腺切除，并检测它们对单独的苯甲酸雌二醇（EB）或EB与孕酮（P）的反应中是否出现脊柱前凸。产前暴露于1毫克或5毫克剂量氟他胺的雄性大鼠，单独给予EB时，其脊柱前凸商显著高于对照组。在所有雄性组中，添加P对雌激素诱导的脊柱前凸没有影响。产前暴露于氟他胺的雌性大鼠，当连续3天每天给予0.175微克或0.25微克EB时，其脊柱前凸商显著高于对照组。在EB治疗中添加P显著促进了对照组和氟他胺处理组雌性大鼠的脊柱前凸表现。产前抗雄激素治疗导致雄性和雌性大鼠雌性性行为增加，这表明产前雄激素会抑制雌性性行为的发育。这种雄激素对性接受能力的抑制（去雌性化）似乎与动物成年后对雌激素的敏感性有关。
