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1-甲基-3-硝基-1-亚硝基胍对细胞内噬菌体的灭活和诱变作用

Inactivating and mutagenic effects of 1-methyl-3-nitro-1-nitrosoguanidine on intracellular bacteriophage.

作者信息

Zampieri A, Greenberg J, Warren G

出版信息

J Virol. 1968 Sep;2(9):901-4. doi: 10.1128/JVI.2.9.901-904.1968.

Abstract

1-Methyl-3-nitro-1-nitrosoguanidine (NG) was able to inactivate and mutate adsorbed but not free coliphage T2. Coliphage T4 was as sensitive to NG as T2. When treatment was delayed for 5 min or longer after adsorption of T2, the phage became increasingly refractory to NG inactivation.

摘要

1-甲基-3-硝基-1-亚硝基胍(NG)能够使吸附的大肠杆菌噬菌体T2失活并发生突变,但对游离的噬菌体T2则不起作用。大肠杆菌噬菌体T4对NG的敏感性与T2相同。当T2吸附后延迟5分钟或更长时间进行处理时,噬菌体对NG失活的抗性就会越来越强。

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