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可乐定对吗啡戒断期间去甲肾上腺素代谢产物水平升高的逆转作用。

Clonidine reversal of increased norepinephrine metabolite levels during morphine withdrawal.

作者信息

Crawley J N, Laverty R, Roth R H

出版信息

Eur J Pharmacol. 1979 Aug 1;57(2-3):247-50. doi: 10.1016/0014-2999(79)90372-8.

DOI:10.1016/0014-2999(79)90372-8
PMID:573692
Abstract

The production of the norepinephrine metabolite 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) in brain regions innervated by the locus coeruleus was increased during naloxone-precipitated withdrawal from chronic morphine treatment. This MHPG increase was reversed by subcutaneous administration of clonidine. Changes in MHPG levels paralleled the elctrophysiological changes found by Aghajanian (1978) in locus coeruleus firing rate with similar treatments, demonstrating the usefulness of MHPG changes as an index of central noradrenergic function.

摘要

在由蓝斑支配的脑区中，去甲肾上腺素代谢产物3-甲氧基-4-羟基苯乙二醇（MHPG）的生成在纳洛酮诱发的慢性吗啡治疗戒断期间增加。皮下注射可乐定可逆转这种MHPG的增加。MHPG水平的变化与阿加贾尼安（1978年）在类似治疗中发现的蓝斑放电率的电生理变化平行，这表明MHPG变化作为中枢去甲肾上腺素能功能指标的有用性。

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Clonidine reversal of increased norepinephrine metabolite levels during morphine withdrawal.可乐定对吗啡戒断期间去甲肾上腺素代谢产物水平升高的逆转作用。
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Pharmacol Res. 2002 May;45(5):407-12. doi: 10.1006/phrs.2002.0962.

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