Coroneo M T, Denniss A R, Young J A
Pflugers Arch. 1979 Sep;381(3):223-30. doi: 10.1007/BF00583253.
The effect of physalaemin, an undecapeptide belonging to a family known collectively as the tachykinins, on water and electrolyte excretion of the mandibular and sublingual salivary glands of the rat has been investigated and compared to that of acetylcholine. Drugs were administered intravenously or by close-arterial infusion. Physalaemin is a powerful stimulant of fluid secretion by both glands although less potent than acetylcholine. The Na and K excretion patterns in physalaemin-evoked saliva resembled, but were by no means identical to those evoked by acetylcholine and other parasympathomimetic drugs: saliva evoked by physalaemin was considerably poorer in Na and K at all secretory rates. The HCO3 excretion curves, on the other hand, seemed to be identical to those evoked by parasympathomimetic drugs. From an analysis of the Na and K excretion patterns, it can be concluded, both for the mandibular and the sublingual glands, that physalaemin stimulated Na reabsorption and K secretion across the gland duct epitheluim, whereas acetylcholine has the opposite effect. These findings agree nicely with what has previously been demonstrated in vitro in the isolated perfused main excretory duct of the rat mandibular gland.
研究了属于速激肽家族的十一肽物质P对大鼠下颌下腺和舌下腺水及电解质排泄的影响，并与乙酰胆碱的作用进行了比较。药物通过静脉注射或动脉近端灌注给药。物质P是这两种腺体液体分泌的强效刺激剂，尽管效力不如乙酰胆碱。物质P诱发的唾液中钠和钾的排泄模式与乙酰胆碱及其他拟副交感神经药物诱发的模式相似，但并不完全相同：在所有分泌速率下，物质P诱发的唾液中钠和钾的含量都明显较低。另一方面，碳酸氢根排泄曲线似乎与拟副交感神经药物诱发的曲线相同。通过对钠和钾排泄模式的分析可以得出结论，对于下颌下腺和舌下腺来说，物质P刺激了钠在腺导管上皮的重吸收和钾的分泌，而乙酰胆碱则具有相反的作用。这些发现与先前在大鼠下颌下腺离体灌注主排泄导管的体外实验结果非常吻合。
