生长激素与肌肉活动在决定肌肉大小方面的关系。
Relationship between growth hormone and muscular work in determining muscle size.
作者信息
Goldberg A L, Goodman H M
出版信息
J Physiol. 1969 Feb;200(3):655-66. doi: 10.1113/jphysiol.1969.sp008714.
Abstract
- Growth hormone reduced the loss of weight or induced net growth of denervated soleus and plantaris muscles in hypophysectomized rats.2. Growth hormone did not alter the weight of the denervated muscle relative to its contralateral control, i.e. the hormone increased the sizes of denervated and control muscles proportionately.3. Similarly treatment with the hormone appeared to cause proportional growth in muscles undergoing work-induced hypertrophy and their contralateral controls.4. It is suggested that muscle size is determined by at least two independent factors, growth hormone and muscular work. Growth hormone appears to act as a biochemical ;amplifying system' for the cell's anabolic machinery and determines the absolute changes in muscle size which result from changes in muscular work.
摘要
- 生长激素减少了垂体切除大鼠失神经支配的比目鱼肌和跖肌的体重减轻或诱导了其净生长。2. 生长激素并未改变失神经支配肌肉相对于其对侧对照的重量，即该激素使失神经支配肌肉和对照肌肉的大小成比例增加。3. 同样，用该激素治疗似乎会使经历工作诱导性肥大的肌肉及其对侧对照成比例生长。4. 有人提出，肌肉大小至少由两个独立因素决定，即生长激素和肌肉活动。生长激素似乎作为细胞合成代谢机制的一种生化“放大系统”，并决定了由肌肉活动变化导致的肌肉大小的绝对变化。
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