Pharmacological investigation of cardiovascular and haemodynamic effects of salts of ioxitalamic acid in anaesthetized dogs.

Aqueous solutions of salts of ioxitalamic acid were infected by intravenous, intracarotid, proximal intra-aortic, and intrafemoral route. We observed cardiovascular effects of small magnitude and short duration. They are composed of hypotension (intravenous and intracarotid route), hypotension followed by hypertension (intra-aortic route), changes of LVP, dLVP/dt and contractile strength parallel with those in blood pressure, bradycardia, increased femoral blood flow. Several factors seemed to be involved in the mechanism of these effects: vagal reflex, transient myocardial depression, peripheral vasodilating effect, increased volaemia. By all routes of administration used, the infection of non-iodinated solutions [NaCl, glucose, methylglucamine (MGL) and monoethanolamine (MEA) hydrochloride] of the same osmolarity as ioxitalamate solution, resulted in similar effects.