Cole E R, Bachmann F
Arch Intern Med. 1976 Apr;136(4):474-9. doi: 10.1001/archinte.136.4.474.
The usefulness of assays for the rapid identification and determination of quantitative plasma levels of warfarin sodium and dicumarol is documented by the case histories of five patients: a man who accidentally took dicumarol for several weeks and developed an acute condition within the abdomen, a man who ingested 500 mg of warfarin sodium in a suicide attempt, a malingering nurse who surreptitiously took dicumarol, a nurse with warfarin intoxication who did not follow dosage prescription because of fear of developing thrombosis, and a woman with calf vein thrombosis who did not ingest the administered warfin sodium becausing of fear of developing bleeding. In every patient, the diagnosis of surreptitious ingestion or noningestion was suspected on the basis of the coagulation profile pattern. Confirmation of the disorder by the spectrophotometric assay enable the clinician to choose the appropriate course of action with speed and purpose.
对华法林钠和双香豆素血浆水平进行快速鉴定和定量测定的分析方法的实用性，通过五名患者的病历得到了证明：一名男子意外服用双香豆素数周并出现腹部急性病症；一名男子为自杀服用了500毫克华法林钠；一名佯装患病的护士偷偷服用双香豆素；一名因害怕形成血栓而未遵循剂量处方的华法林中毒护士；一名因害怕出血而未服用所给华法林钠的小腿静脉血栓形成的女性。在每一位患者中，基于凝血谱模式怀疑有偷偷服药或未服药的情况。通过分光光度法分析对病症的确认，使临床医生能够迅速且有针对性地选择合适的治疗方案。
